NIH links higher dose of DHA with lower early preterm birth rate

Women taking 1,000 mg of DHA daily in the last half of pregnancy had a lower rate of early preterm birth than women who took the standard 200 mg dose

Women taking 1,000 mg of docosohexanoic acid (DHA) daily in the last half of pregnancy had a lower rate of early preterm birth than women who took the standard 200 mg dose, according to a study funded by the National Institutes of Health (NIH). Women who entered the study with the lowest DHA level had the greatest reduction in early preterm birth, which is birth before 34 weeks of pregnancy and which increases the risk of infant death and disability.

The study was conducted by Susan E Carlson, PhD, at the University of Kansas Medical Center, Kansas City, and colleagues. It appears in EClinicalMedicine. Funding was provided by NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

Previous studies on DHA and other omega-3 fatty acids, which are nutrients found in fish and eggs and supplements like algal oil, and their possible effects on the rate of early preterm birth have been inconclusive and have not identified a specific type or dose of omega-3 fatty acids.

Researchers enrolled nearly 1,100 women and compared the early preterm birth rate of women given 1,000 mg of DHA to those given 200 mg. Overall, 1.7 per cent of women in the high dose group delivered early preterm compared to 2.4 per cent in the standard-dose group. Women in the high dose group with low DHA levels at study entry had the greatest reduction in early preterm birth (2 per cent rate, compared to a 4.1 per cent rate for those with low DHA levels on the standard dose). Among women who had high DHA levels at study entry, the rate of early preterm birth was low and did not differ by dose (1.4 per cent vs. 1.1 per cent).