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Latest research has revealed that consumption of low-calorie sweeteners could promote metabolic syndrome and predispose people to prediabetes and diabetes, particularly in individuals with obesity. The study was conducted on human fat-derived stem cells and fat samples.
In addition to stem cells, the US researchers also studied human fat samples collected from individuals with obesity who consumed low-calorie sweeteners. They found similar changes in gene expression in the same genes with increased activity of glucose transporters in both the stem cells and the fat cells.
The researchers tested sucralose, a popular low-calorie sweetener, on stem cells- cells that could change into mature fat, muscle, cartilage or bone cells, taken from human fat tissue. They observed increased expression of genes that are markers of fat production and inflammation.
In a separate study, the team found that sucralose appears to promote oxygen radical accumulation – a highly reactive particles that can cause disease and inflammation inside cells. These oxygen radicals interfere with cell activity and slow down metabolism, which promotes accumulation of fat in the cell.