Kyowa Hakko USA announces GRAS self-affirmation for L-Citrulline amino acid


Kyowa Hakko USA, the wholly owned subsidiary of Kyowa Hakko Bio Co. Ltd., announced that it has completed GRAS (Generally Recognized As Safe) self-affirmation for the amino acid L-Citrulline.

L-Citrulline is an amino acid that plays an important role in nitric oxide (NO) metabolism and regulation. L-Citrulline is converted to L-Arginine in the body to support L-Arginine and NO levels. Increased production of NO promotes vascular dilation which improves oxygen and blood circulation throughout the body. L-Citrulline is also expected to relieve muscle fatigue through ammonia elimination. Antioxidant action and heart protection are also known.

“We are extremely proud to announce GRAS for our amino acid L-Citrulline, and look forward to working with manufactures to incorporate it into foods and beverages,” said Dr. Toshikazu Kamiya, President & CEO of Kyowa Hakko USA.

L-Citrulline is preservative-free, allergen-free, and contains no artificial flavors or colors, said Kyowa. It is manufactured in the US using a proprietary fermentation process.

L-Citrulline will be marketed by Kyowa Hakko USA as a food ingredient in the US for use at levels of 275 mg of L-Citrulline/serving up to a maximum of 2000 mg/day in various food products, such as beverages and beverages bases; grain products and pastas; and milk products.

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