Shimadzu has released the ‘Prominence UFPLC’ Ultra-Fast Preparative and Purification Liquid Chromatograph, which enables fast recovery of highly purified target compounds from complex samples such as organic synthesis reaction mixtures and natural products.
Conventional workflows that utilise preparative liquid chromatography (Prep LC) yield fractions with significant water content, which can take eight hours or more to evaporate and typically cannot be completely removed, resulting in a powder with poor weight purity.
The Prominence UF- PLC is a single automated workflow that utilises on-line fraction trapping as an alternative to traditional fraction collection, allowing elution of collected compounds in highly volatile organic solvents that can easily be evaporated, resulting in ultra-high weight purity compounds in about 90 minutes. The Prominence UFPLC greatly improves the efficiency of preparative fraction collection and purification workflows in pharmaceutical, food, chemical and other industries as well as research organisations.
Prep LC is a widely used technique in many research, development and manufacturing applications, including the synthesis of new drug compounds, the discovery of active components in natural products, and as a mechanism to collect large amounts of unknown compounds in foods and drugs for subsequent structural analysis.
In 2013, Shimadzu released the ‘Crude2Pure’ Auto- mated Purification/Powderisation System, which accepted PrepLC fractions, removed mobile phase contaminants, and returned a highly pure and very dry powder, with an option to recover that powder as a free base. Prominence UFPLC inherits the breakthrough fraction trapping and purification technology at the core of Crude2Pure and expands on it to provide a comprehensive on- line automated purification process.
The Prominence UFPLC seamlessly integrates traditional Prep LC with novel fraction trapping for up to five compounds of interest. The instrument is controlled by a dedicated walk-up software designed to empower non-expert users to easily set conditions for chromatographic separation and isolation of target com- pounds, trapping, purifying, eluting and collecting highly purified com- pounds in as little as 90 minutes. For applications involving the isolation of low concentration targets, replicate injection and collection to the same trapping column to increase the amount of compound trapped on column prior to elution is easily accomplished.
With the introduction of Prominence UFPLC, Shimadzu expands its extensive chromatography portfolio to include a comprehensive automated solution for preparative separations, fraction purification and compound powderisation, contributing greatly to improved efficiency in any application that requires preparative purification.Shimadzu releases ultra-fast preparative and purification liquid chromatograph.
Shimadzu has released the ‘Prominence UFPLC’ Ultra-Fast Preparative and Purification Liquid Chromatograph, which enables fast recovery of highly purified target compounds from complex samples such as organic synthesis reaction mixtures and natural products.
Conventional workflows that utilise preparative liquid chromatography (Prep LC) yield fractions with significant water content, which can take eight hours or more to evaporate and typically cannot be completely removed, resulting in a powder with poor weight purity.
The Prominence UF- PLC is a single automated workflow that utilises on-line fraction trapping as an alternative to traditional fraction collection, allowing elution of collected compounds in highly volatile organic solvents that can easily be evaporated, resulting in ultra-high weight purity compounds in about 90 minutes. The Prominence UFPLC greatly improves the efficiency of preparative fraction collection and purification workflows in pharmaceutical, food, chemical and other industries as well as research organisations.
Prep LC is a widely used technique in many research, development and manufacturing applications, including the synthesis of new drug compounds, the discovery of active components in natural products, and as a mechanism to collect large amounts of unknown compounds in foods and drugs for subsequent structural analysis.
In 2013, Shimad- zu released the ‘Crude2Pure’ Auto- mated Purification/Powderisation System, which accepted PrepLC fractions, removed mobile phase contaminants, and returned a highly pure and very dry powder, with an option to recover that powder as a free base. Prominence UFPLC inherits the breakthrough fraction trapping and purification technology at the core of Crude2Pure and expands on it to provide a comprehensive on- line automated purification process.
The Prominence UFPLC seamlessly integrates traditional Prep LC with novel fraction trapping for up to five compounds of interest. The instrument is controlled by a dedicated walk-up software designed to empower non-expert users to easily set conditions for chromatographic separation and isolation of target com- pounds, trapping, purifying, eluting and collecting highly purified com- pounds in as little as 90 minutes. For applications involving the isolation of low concentration targets, replicate injection and collection to the same trapping column to increase the amount of compound trapped on column prior to elution is easily accomplished.
With the introduction of Prominence UFPLC, Shimadzu expands its extensive chromatography portfolio to include a comprehensive automated solution for preparative separations, fraction purification and compound powderisation, contributing greatly to improved efficiency in any application that requires preparative purification.
Shimadzu releases ultra-fast preparative and purification liquid chromatograph
