New drug delivery system is simple, cost-effective, safe, and has significant translational potential
A newly synthesised biocompatible therapeutic nano-micelle drug delivery system combined with anti-inflammatory drugs has shown improved potential to cure rheumatoid arthritis (RA) at the lab level. It can help ameliorate the pain associated with the disease as well as cure the disease by restoring cartilage integrity which provides the flexibility to the bone.
Scientists from Institute of Nano Science and Technology (INST), Mohali, an autonomous institute of Department of Science and Technology, explored the potential of the anti-inflammatory FDA-approved drug 9-aminoacridine (9AA) and the natural compound caffeic acid (CA), generally found in coffee or wine (reported to possess significant anti-arthritic potential) conjugated to nano micelles, an amphiphilic molecule that forms spherical structure when immersed in water, for the treatment of RA.
Inflammation plays an important role in the development of rheumatoid arthritis. As a result, strategies for treating RA have been largely focused on providing symptomatic relief from pain and permanent cure is not available to date. Methotrexate (MTX) is considered as golden standard for the therapy of the disease but due to its severe side effects, researchers are currently looking for alternate drugs or strategies to overcome the disease.
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